Further, several important regulators of systemic/pulmonary hypertension including ADRA1D, ECE1, and EDNRA were upregulated in HAPE. Some notable genes within these pathways included MYLK rho family members ARGEF11, ARHGAP24 cell adhesion molecules such as CLDN6, CLDN23, PXN and VCAM1 besides other signaling intermediates. These pathways included those which regulate vasoconstriction through smooth muscle contraction, cellular actin cytoskeleton rearrangements and endothelial permeability/dysfunction. Our data suggests concurrent modulation of multiple pathways which regulate vascular homeostasis and consequently lung fluid dynamics.
We performed global gene expression profiling in individuals with established HAPE compared to acclimatized individuals.
0 kommentar(er)
